CHAC2抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: Mouse heart tissue, Primary antibody: P07687(TPM1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07687(TPM1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07687(TPM1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

**Background of CHAC2 Antibody**

The CHAC2 (cation transport regulator-like protein 2) antibody is a tool used to detect and study the CHAC2 protein, a member of the CHAC family of glutathione (GSH)-degrading enzymes. CHAC2. also known as MGC4509. shares structural and functional homology with CHAC1. both of which catalyze the cleavage of glutathione into 5-oxoproline and cysteinylglycine via their γ-glutamylcyclotransferase activity. This process plays a role in regulating intracellular redox balance, impacting cellular responses to oxidative stress, apoptosis, and metabolic pathways.

CHAC2 is ubiquitously expressed but shows tissue-specific variations, with higher levels observed in the liver, kidney, and heart. Its biological significance is linked to diseases involving oxidative damage, such as neurodegenerative disorders, cancer, and cardiovascular conditions. Studies suggest CHAC2 may influence cell survival under stress by modulating GSH levels, though its precise mechanisms remain less characterized compared to CHAC1.

Antibodies against CHAC2 are essential for elucidating its expression patterns, subcellular localization, and interactions in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing CHAC2 antibodies has contributed to understanding its role in endoplasmic reticulum (ER) stress responses and potential therapeutic targeting in redox-related diseases. Ongoing studies aim to clarify its distinct functions and regulatory networks within cellular antioxidant defense systems.