CXXC1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09491(CXXC1 Antibody) at dilution 1/130. (Original magnification: ×200)    

  
  

The CXXC1 antibody is a research tool targeting the CXXC-type zinc finger protein 1 (CXXC1), also known as CFP1 or CGBP. CXXC1 is a nuclear protein containing a conserved CXXC domain that binds unmethylated CpG dinucleotides, enabling its role in epigenetic regulation. It serves as a critical component of the SETD1 histone methyltransferase complex, facilitating H3K4 trimethylation (H3K4me3), a histone modification associated with active gene promoters. CXXC1 also interacts with the TET enzymes, which catalyze DNA demethylation, linking it to DNA methylation dynamics.

CXXC1 is essential for embryonic development and cellular differentiation, influencing processes like hematopoiesis and stem cell maintenance. Dysregulation of CXXC1 is implicated in cancers, particularly leukemias, where aberrant DNA methylation or histone modification patterns contribute to oncogenesis. The CXXC1 antibody is widely used in techniques such as chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to study its localization, protein interactions, and regulatory roles in gene expression. Researchers employ this antibody to explore mechanisms of epigenetic inheritance, DNA repair, and disease-related epigenetic alterations. Its specificity and reliability make it a key reagent in dissecting the interplay between chromatin modifiers, DNA methylation, and transcriptional regulation in health and disease.