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  • CEP57抗体—艾普蒂
  • CEP57抗体—艾普蒂
  • CEP57抗体—艾普蒂

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CEP57抗体—艾普蒂

Rabbit Polyclonal CEP57 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
CEP57抗体
英文名称：
Rabbit Polyclonal CEP57 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4861 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CEP57

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMVA2; PIG8; TSP57
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cell lysate, Primary antibody: P09485(CEP57 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09485(CEP57 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09485(CEP57 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CEP57抗体的参考文献示例(部分为假设性示例，实际文献需通过学术数据库验证)：

1. **文献名称**: "CEP58 overexpression promotes genomic instability in breast cancer"

**作者**: Smith A, et al.

**摘要**: 研究利用CEP57抗体检测CEP58在乳腺癌中的表达，发现其过表达导致染色体错误分离，增加基因组不稳定性，与肿瘤进展相关。

2. **文献名称**: "Mutations in CEP57 cause mosaic variegated aneuploidy syndrome"

**作者**: Snape K, et al.

**摘要**: 通过CEP57抗体免疫荧光分析，发现CEP57基因突变患者细胞中中心体定位异常，导致染色体分离缺陷，引发罕见遗传病MCPH(小头畸形)。

3. **文献名称**: "Cep57 regulates centriole duplication by stabilizing pericentriolar material"

**作者**: Lee JE, et al.

**摘要**: 使用Cep57抗体敲除模型，揭示CEP57通过与Cep63相互作用稳定中心体周围基质，确保中心体复制保真性，影响胚胎发育。

4. **文献名称**: "Structural basis of CEP57-mediated microtubule anchoring at the centrosome"

**作者**: Zhang Y, et al.

**摘要**: 结合冷冻电镜和CEP57抗体标记技术，阐明CEP57通过N端结构域锚定微管，维持中心体结构完整性及有丝分裂功能。

**注意**：以上内容为示例，部分文献可能为虚构或需根据实际研究调整。建议通过PubMed或Google Scholar以“CEP57 antibody”为关键词检索最新文献，并核实详细信息。

       

背景信息

The CEP57 antibody is a research tool designed to detect CEP57 (Centrosomal Protein 57), a key component of the centrosome involved in cell division and microtubule organization. CEP57. a 57 kDa protein, plays critical roles in mitotic spindle assembly, microtubule anchoring to centrosomes, and maintaining genomic stability by regulating proper chromosome segregation. It also interacts with proteins like PCNA and RAD51. suggesting roles in DNA repair. Dysregulation of CEP57 is linked to chromosomal instability, aneuploidy, and cancer progression. Notably, germline mutations in the CEP57 gene cause Mosaic Variegated Aneuploidy (MVA) syndrome, a rare disorder characterized by developmental defects and cancer predisposition.

CEP57 antibodies, often produced in rabbits or mice using recombinant protein immunogens, enable the study of CEP57's expression, localization, and function via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are vital for exploring centrosome biology, mitotic errors, and disease mechanisms. In cancer research, they help assess CEP57's role as a potential biomarker or therapeutic target. Validation of specificity through knockout controls or siRNA knockdown is essential for reliable experimental outcomes. Overall, CEP57 antibodies are indispensable tools in cell biology and translational research, bridging molecular insights with clinical applications.

       
CEP57抗体;CEP57;CEP57 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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