CEP72抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: TM4, NIH/3T3 and Jurkat cell lysates, Primary antibody: P09482(CEP72 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09482(CEP72 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09482(CEP72 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

CEP72 antibody is a research tool targeting the centrosomal protein CEP72. a key component involved in centrosome maturation and spindle pole organization during cell division. CEP72. encoded by the *CEP72* gene, plays a critical role in maintaining genomic stability by ensuring proper microtubule nucleation and mitotic spindle assembly. Dysregulation of CEP72 has been linked to microcephaly, neurodevelopmental disorders, and cancer due to its role in preventing chromosome missegregation and aneuploidy.

The CEP72 antibody is primarily used in immunoblotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study CEP72 expression, localization, and interactions in cellular models or tissue samples. Researchers employ it to explore mechanisms underlying centrosomal defects, mitotic errors, and diseases associated with centrosome amplification. Recent studies have also investigated CEP72's potential as a biomarker or therapeutic target in cancers, particularly those with centrosome-related genomic instability.

Commercial CEP72 antibodies are typically raised in rabbits or mice using recombinant protein fragments, and validation includes specificity checks via knockdown/knockout controls. Its utility spans basic cell biology, clinical research, and drug development, making it vital for understanding centrosome biology and pathologies linked to mitotic dysregulation.