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  • CCNB1IP1抗体—艾普蒂
  • CCNB1IP1抗体—艾普蒂
  • CCNB1IP1抗体—艾普蒂

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CCNB1IP1抗体—艾普蒂

Rabbit Polyclonal CCNB1IP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：ruihening88@163.com

产品详情:

中文名称：
CCNB1IP1抗体
英文名称：
Rabbit Polyclonal CCNB1IP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4837 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CCNB1IP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHEI10; C14orf18
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 and HT-29 cell lysates, Primary antibody: P09449(CCNB1IP1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09449(CCNB1IP1 Antibody) at dilution 1/25. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09449(CCNB1IP1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于CCNB1IP1抗体的参考文献示例(注：以下为模拟内容，实际文献需通过学术数据库检索确认)：

1. **文献名称**: "CCNB1IP1 regulates cell cycle progression in breast cancer via ubiquitination"

**作者**: Zhang et al.

**摘要**: 本研究通过Western blot和免疫荧光技术，使用CCNB1IP1抗体验证其在乳腺癌细胞中的表达及定位，发现其通过泛素化调控Cyclin B1的稳定性，影响细胞周期G2/M期转换。

2. **文献名称**: "The role of CCNB1IP1 in meiotic recombination and fertility"

**作者**: Smith et al.

**摘要**: 利用CCNB1IP1特异性抗体进行免疫组化分析，揭示其在生殖细胞减数分裂中的关键作用，表明其缺失导致染色体联会异常和不育表型。

3. **文献名称**: "CCNB1IP1 interacts with Aurora kinase in mitotic regulation"

**作者**: Tanaka et al.

**摘要**: 通过免疫共沉淀(Co-IP)结合CCNB1IP1抗体，证明其与Aurora激酶的相互作用，并调控有丝分裂纺锤体组装及染色体分离。

4. **文献名称**: "CCNB1IP1 as a biomarker in hepatocellular carcinoma"

**作者**: Wang et al.

**摘要**: 采用CCNB1IP1抗体对肝癌组织进行染色，发现其高表达与患者预后不良相关，提示其作为潜在治疗靶点的可能性。

建议通过PubMed或Google Scholar以“CCNB1IP1 antibody”为关键词检索最新文献获取具体信息。

       

背景信息

**Background of CCNB1IP1 Antibody**

CCNB1IP1 (Cyclin B1 Interacting Protein 1), also known as E3 ubiquitin-protein ligase CCNB1IP1 or HEI10. is a critical regulator of cell cycle progression, particularly in meiosis and mitosis. It functions as an E3 ubiquitin ligase, facilitating homologous recombination repair (HRR) by promoting the ubiquitination and degradation of specific substrates, thereby ensuring genomic stability. CCNB1IP1 interacts with Cyclin B1. a key component of the maturation-promoting factor (MPF), to regulate the G2/M transition and mitotic exit.

Antibodies targeting CCNB1IP1 are essential tools for studying its expression, localization, and molecular interactions in cellular processes. They are widely used in techniques such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to investigate CCNB1IP1's role in DNA repair, cell cycle checkpoints, and chromosome dynamics. Dysregulation of CCNB1IP1 has been linked to cancer (e.g., impaired HRR in tumors) and reproductive disorders (e.g., meiotic defects leading to infertility). Research utilizing CCNB1IP1 antibodies has provided insights into its tumor-suppressive functions and potential as a therapeutic target. These antibodies are also employed in model organisms to dissect conserved mechanisms of genome maintenance. Validated specificity and proper experimental controls are crucial for reliable data interpretation.

       
CCNB1IP1抗体;CCNB1IP1;CCNB1IP1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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