CABP5抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09420(CABP5 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09420(CABP5 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

The CABP5 (Calcium-Binding Protein 5) antibody is a tool used to detect and study the expression of the CABP5 protein, a member of the calcium-binding protein (CaBP) family. CABP5 is primarily expressed in retinal neurons, particularly in cone photoreceptor bipolar cells, where it modulates calcium signaling and synaptic transmission. It plays a role in regulating phototransduction and maintaining visual signal fidelity by interacting with voltage-gated calcium channels (e.g., Cav1.4) and influencing calcium homeostasis. Dysregulation of CABP5 has been linked to retinal disorders, including congenital cone-rod synaptic defects and vision impairment.

The CABP5 antibody is widely utilized in neuroscience and ophthalmology research to investigate retinal circuitry, calcium-dependent signaling mechanisms, and disease pathology. It enables localization of CABP5 in tissue sections (via immunohistochemistry) and quantification in protein extracts (via Western blot). Recent studies also explore its potential as a biomarker for retinal degenerative diseases. Developed in various host species (e.g., rabbit, mouse), CABP5 antibodies are validated for specificity and cross-reactivity across model organisms like mice and primates. Their applications extend to understanding neural plasticity and developing therapeutic strategies for vision-related disorders.