FAM110B抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Mouse liver tissue, Mouse brain tissue, Rat brain tissue, Rat liver tissue and Human fetal liver tissue lysates, Primary antibody: P02867(QDPR Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02867(QDPR Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P02867(QDPR Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

FAM110B (Family with sequence similarity 110 member B) is a protein-coding gene with limited functional characterization, though emerging studies suggest roles in cell cycle regulation and cytoskeletal organization. It belongs to the FAM110 family, which includes proteins implicated in mitotic progression and centrosome-related processes. FAM110B is proposed to localize to the nucleus and cytoplasm, potentially interacting with microtubules during the G2/M phase. Its exact molecular mechanisms remain unclear, but dysregulation has been linked to cellular proliferation anomalies and cancer progression.

Antibodies targeting FAM110B are essential tools for investigating its expression, subcellular localization, and functional pathways. These antibodies (often rabbit or mouse-derived polyclonal/monoclonal) enable techniques like Western blotting, immunofluorescence, and immunohistochemistry. Validation typically includes testing reactivity in human, mouse, or rat samples, with observed molecular weights around 50-60 kDa.

Recent studies associate FAM110B overexpression with hepatocellular carcinoma and colorectal cancer, suggesting its potential as a biomarker or therapeutic target. However, research gaps persist, necessitating further exploration of its interactions (e.g., with mitotic spindle proteins) and disease-specific roles. FAM110B antibodies thus serve as critical reagents for advancing both basic and translational studies in cell biology and oncology.