C5AR1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09415(C5AR1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09415(C5AR1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

C5aR1 (C5a receptor 1), also known as CD88. is a G protein-coupled receptor (GPCR) that binds to the complement component C5a, a potent pro-inflammatory peptide generated during complement system activation. This receptor plays a central role in inflammatory and immune responses by mediating chemotaxis, cytokine release, and leukocyte activation. Dysregulation of C5a-C5aR1 signaling is implicated in various pathological conditions, including sepsis, rheumatoid arthritis, inflammatory bowel disease, and cancer progression, making it a therapeutic target of interest.

C5aR1 antibodies are tools designed to modulate this pathway. As research reagents, they enable the detection and quantification of C5aR1 expression in cells and tissues, aiding mechanistic studies. Therapeutically, neutralizing antibodies against C5aR1 or C5a aim to disrupt the receptor-ligand interaction, thereby attenuating excessive inflammation. For example, antagonists blocking C5aR1 have shown potential in preclinical models of autoimmune diseases and acute inflammatory syndromes. Conversely, agonist antibodies might be explored in contexts requiring immune activation, such as enhancing antitumor responses.

Recent advances include the development of humanized monoclonal antibodies and small-molecule inhibitors targeting C5aR1. with several candidates in clinical trials for conditions like COVID-19-associated lung injury and hidradenitis suppurativa. Challenges remain in balancing efficacy with safety, as broad suppression of C5aR1 may compromise host defense. Ongoing research focuses on optimizing antibody specificity, pharmacokinetics, and tissue targeting to improve therapeutic outcomes.