KLHL12抗体—艾普蒂

The KLHL12 antibody is a tool used to detect Kelch-like protein 12 (KLHL12), a member of the Kelch-like (KLHL) family involved in substrate recognition for Cullin3 (CUL3)-based E3 ubiquitin ligase complexes. KLHL12 plays critical roles in cellular processes, including protein ubiquitination, trafficking, and degradation. Structurally, it contains a BTB domain for CUL3 binding and Kelch repeats for substrate interaction. Research highlights its regulation of secretory pathway components, such as the corticotropin-releasing hormone receptor (CRHR1), and its involvement in Wnt/β-catenin signaling by targeting Dishevelled (DVL) proteins for ubiquitination. Dysregulation of KLHL12 is linked to diseases like cancer, metabolic disorders, and neurological conditions. The KLHL12 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in various tissues and disease models. It aids in exploring KLHL12's role in cellular homeostasis, stress responses, and pathological mechanisms, offering insights into potential therapeutic targets. Commercial KLHL12 antibodies are validated for specificity and reproducibility, supporting both basic and translational research in molecular biology and medicine.