CATSPERE抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09399(CATSPERE Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

CATSPER (Cation Channel of Sperm) is a sperm-specific ion channel complex essential for male fertility. Comprising four pore-forming subunits (CATSPER1-4) and auxiliary proteins (CATSPERE, CATSPERβ, γ, δ), it regulates calcium influx into sperm, enabling hyperactivated motility, capacitation, and zona pellucida penetration during fertilization. CATSPERE (formerly CATSPERζ) is a recently identified transmembrane subunit critical for channel assembly, trafficking, and function. Studies show CATSPERE interacts with other subunits to stabilize the channel structure and modulate calcium signaling.

Research on CATSPERE antibodies emerged to explore its expression patterns, localization, and functional roles. These antibodies, often developed in rabbits or mice using peptide immunogens, enable detection of CATSPERE in sperm via techniques like Western blot, immunofluorescence, and immunohistochemistry. Knockout models and antibody-based studies reveal that CATSPERE deficiency disrupts channel activity, causing male infertility due to impaired sperm motility and fertilization defects. Mutations in CATSPERE are linked to human male infertility, highlighting its clinical relevance.

CATSPERE antibodies are vital tools in reproductive biology, aiding in diagnosing idiopathic infertility and developing contraceptives targeting the CATSPER complex. Their application extends to studying calcium signaling mechanisms in sperm physiology, offering insights into therapeutic strategies for fertility disorders.