BBOF1抗体—艾普蒂

The BBOF1 antibody targets the BBOF1 protein, a component of the HAUS complex involved in microtubule nucleation and mitotic spindle assembly. BBOF1 (also known as HAUS6) contributes to chromosomal segregation during cell division by stabilizing γ-tubulin ring complexes, critical for proper microtubule organization. Dysregulation of BBOF1 is linked to mitotic errors, genomic instability, and diseases like cancer. Researchers use BBOF1 antibodies to study its expression, localization, and interactions in cell cycle regulation, often employing techniques such as immunofluorescence, Western blotting, or co-immunoprecipitation. These antibodies help elucidate mechanisms of spindle assembly, mitotic progression, and potential roles in tumorigenesis. Commercial BBOF1 antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls. Their applications span basic cell biology, cancer research, and drug discovery targeting mitotic pathways.