INF2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09386(INF2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

INF2 (Inverted Formin 2) antibodies are tools used to study the role of the INF2 protein, a member of the formin family involved in regulating actin cytoskeleton dynamics. INF2 is unique among formins due to its ability to both promote actin polymerization and depolymerization, playing critical roles in cellular processes like mitochondrial fission, cell migration, and intracellular vesicle trafficking. Mutations in the *INF2* gene are linked to human diseases, notably autosomal dominant focal segmental glomerulosclerosis (FSGS), a kidney disorder, and Charcot-Marie-Tooth disease (CMT), a peripheral neuropathy.

INF2 antibodies are essential for detecting protein expression, localization, and post-translational modifications in research models. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate INF2's interaction with other cytoskeletal regulators (e.g., CDC42. microtubules) and its dysfunction in disease contexts. Studies using these antibodies have revealed INF2's dual role in maintaining podocyte structure in kidneys and regulating mitochondrial morphology in neurons, providing insights into disease mechanisms. Commercial INF2 antibodies are typically raised against specific epitopes, often validated in knockout controls to ensure specificity. Their application continues to advance understanding of cytoskeletal disorders and potential therapeutic targets.