UBR7抗体—艾普蒂

The UBR7 antibody is a research tool used to study the ubiquitin-protein ligase E3 component n-recognin 7 (UBR7), a member of the UBR box-containing protein family. UBR7 is implicated in the N-end rule pathway, a ubiquitin-dependent proteolytic system that targets specific proteins for degradation based on their N-terminal residues. Unlike other UBR family members (e.g., UBR1-UBR6), UBR7 uniquely associates with chromatin and regulates transcriptional processes, potentially through histone modification or chromatin remodeling. It contains a plant homeodomain (PHD) finger, suggesting roles in epigenetic regulation. Studies link UBR7 to tumor suppression, DNA repair, and cell cycle control, with dysregulation observed in cancers and developmental disorders. The UBR7 antibody enables detection and localization of UBR7 in cells or tissues via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Its development aids investigations into UBR7's molecular mechanisms, including its interplay with polycomb repressive complexes or p53-mediated pathways. Validating antibody specificity through knockout controls or siRNA knockdown is critical due to potential cross-reactivity with homologous proteins. Research using UBR7 antibodies contributes to understanding diseases linked to ubiquitin-proteasome dysfunction and chromatin biology.