NCAPH抗体—艾普蒂

The NCAPH antibody targets the Non-SMC Condensin I Complex Subunit H (NCAPH), a key component of the condensin I complex essential for chromosome condensation and segregation during mitosis. Condensin I, composed of SMC2. SMC4. and three non-SMC subunits (NCAPD2. NCAPH, and NCAPG), ensures proper chromatin organization by compacting chromosomes and resolving sister chromatids. NCAPH stabilizes the complex, enabling ATPase-driven structural changes critical for DNA loop formation and mitotic fidelity. Dysregulation of NCAPH is linked to genomic instability, aneuploidy, and cancer progression. NCAPH antibodies are widely used in research to study chromosome dynamics, cell cycle regulation, and mitotic errors. They enable detection via Western blotting, immunofluorescence, and immunohistochemistry, helping elucidate NCAPH's role in developmental disorders and malignancies. Recent studies highlight its overexpression in tumors, correlating with poor prognosis, making it a potential therapeutic target. These antibodies also aid in exploring condensin I's interaction with other chromatin modifiers and its involvement in DNA repair. Available as monoclonal or polyclonal variants, NCAPH antibodies are vital tools for understanding genome organization and mitotic mechanisms.