BRPF3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09374(BRPF3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The BRPF3 (Bromodomain and PHD Finger-containing Protein 3) antibody is a tool used to detect and study the BRPF3 protein, a member of the BRPF family involved in epigenetic regulation. BRPF3 acts as a regulatory subunit of histone acetyltransferase (HAT) complexes, such as the MOZ/MORF complex, which modulate chromatin structure and gene expression by acetylating histones. This protein contains conserved bromodomains and PHD fingers that facilitate interactions with acetylated histones or other chromatin-associated proteins, playing roles in transcriptional activation, cellular differentiation, and development.

BRPF3 antibodies are widely utilized in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate BRPF3’s expression, localization, and molecular interactions. These antibodies help elucidate BRPF3’s involvement in diseases, particularly cancers (e.g., leukemia) and neurodevelopmental disorders, where dysregulation of epigenetic modifiers is common. Validated for specificity, BRPF3 antibodies are often tested in knockout cell lines or tissues to confirm minimal cross-reactivity with related family members (e.g., BRPF1/2). Research using these antibodies has highlighted BRPF3’s role in maintaining stem cell pluripotency and regulating developmental pathways. Commercial BRPF3 antibodies are typically raised against epitopes in the N-terminal or central regions, with reactivity across human, mouse, and rat samples. Their applications extend to both basic research and therapeutic target validation in epigenetics-focused studies.