MCPH1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09373(MCPH1 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09373(MCPH1 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

The MCPH1 antibody targets the Microcephalin protein, encoded by the *MCPH1* gene, which plays a critical role in regulating brain development and maintaining genomic stability. First identified through mutations linked to autosomal recessive primary microcephaly, MCPH1 is essential for proper neurogenesis, particularly in controlling cerebral cortex size by modulating neuronal progenitor proliferation and differentiation. The protein contains BRCT domains, enabling interactions with DNA damage response (DDR) proteins, and is involved in cell cycle checkpoints, particularly the G2/M transition, ensuring proper chromosome condensation and repair.

MCPH1 antibodies are widely used in research to study protein expression, localization, and function in cellular models, including Western blotting, immunofluorescence, and co-immunoprecipitation. They help elucidate MCPH1's roles in DDR pathways, centrosome regulation, and chromatin remodeling. Dysregulation of MCPH1 is also implicated in cancer, as altered expression correlates with genomic instability and tumor progression. Commercial MCPH1 antibodies are typically raised against specific epitopes (e.g., human N-terminal regions) and validated for cross-reactivity in common model organisms. However, variability in antibody specificity necessitates careful validation for experimental reproducibility. Research using these antibodies continues to advance understanding of neurodevelopmental disorders and cancer biology.