BPGM抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P09366(BPGM Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09366(BPGM Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09366(BPGM Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

**Background of BPGM Antibodies**

BPGM (bisphosphoglycerate mutase) is a critical enzyme in erythrocyte metabolism, primarily regulating 2.3-bisphosphoglycerate (2.3-BPG) levels, which modulate hemoglobin’s oxygen-binding affinity. By controlling 2.3-BPG concentrations, BPGM ensures optimal oxygen delivery to tissues, particularly under hypoxic conditions. Dysregulation of BPGM activity is linked to disorders like anemia, sickle cell disease, and hypoxia adaptation challenges.

BPGM antibodies are immunological tools developed to detect and quantify BPGM expression in research and diagnostic settings. These antibodies enable the study of BPGM’s role in cellular energy metabolism, erythrocyte function, and disease mechanisms. They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to assess protein expression patterns in tissues or cultured cells.

In research, BPGM antibodies contribute to understanding genetic mutations affecting enzyme activity and their association with metabolic disorders. Clinically, they hold potential for diagnosing rare BPGM deficiencies or monitoring conditions characterized by altered oxygen transport. Recent studies also explore BPGM’s involvement in cancer metabolism, highlighting its broader therapeutic relevance.

Overall, BPGM antibodies serve as vital reagents for unraveling the enzyme’s physiological and pathological roles, bridging insights into oxygen homeostasis, disease mechanisms, and targeted therapies.