BOLA1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09365(BOLA1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09365(BOLA1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The BOLA1 antibody targets the BolA family member 1 protein, a highly conserved protein implicated in cellular iron-sulfur (Fe-S) cluster metabolism and redox homeostasis. BOLA1 is localized to mitochondria and interacts with glutaredoxin-5 (GLRX5), playing a role in Fe-S cluster biogenesis—a critical process for enzymes involved in DNA repair, energy production, and antioxidant defense. Studies suggest BOLA1 may act as a redox-sensitive regulator, balancing Fe-S cluster distribution under oxidative stress conditions.

BOLA1 antibodies are primarily used in research to investigate mitochondrial dysfunction, oxidative stress-related diseases, and Fe-S cluster-associated disorders. They enable detection of BOLA1 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Emerging evidence links BOLA1 dysregulation to neurodegenerative diseases, cancer, and rare genetic disorders, driving interest in its mechanistic roles.

Despite its conserved structure across eukaryotes, BOLA1's precise molecular functions remain under exploration. Antibodies against BOLA1 help clarify its tissue-specific expression patterns, subcellular localization, and interaction networks. Recent studies also explore its potential as a biomarker for mitochondrial pathologies. However, commercial availability of BOLA1 antibodies is limited, emphasizing the need for rigorous validation to ensure specificity in experimental models. Ongoing research aims to unravel its therapeutic relevance in diseases tied to Fe-S cluster imbalance.