BEX1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09359(BEX1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09359(BEX1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The BEX1 (Brain Expressed X-linked 1) antibody is a tool used to detect the BEX1 protein, encoded by the *BEX1* gene located on the X chromosome. Initially identified for its neural expression during brain development, BEX1 is implicated in neuronal differentiation, apoptosis regulation, and cell cycle control. It interacts with signaling pathways like TrkA and NF-κB, influencing neurodevelopment and cancer progression. In oncology, BEX1 exhibits dual roles: it acts as a tumor suppressor in gliomas by inhibiting proliferation or as an oncogene in breast cancer and neuroblastoma, depending on cellular context. Dysregulated BEX1 expression correlates with prognosis in certain cancers, making it a potential biomarker.

The BEX1 antibody is widely utilized in research applications—Western blotting, immunohistochemistry, and immunofluorescence—to study BEX1’s localization and expression patterns. Commercial antibodies are typically generated using recombinant proteins or synthetic peptides, with validation in specific experimental models. Despite its utility, variability in antibody specificity across studies highlights the need for rigorous validation. Ongoing research focuses on clarifying BEX1’s mechanistic roles in development and disease, particularly its interplay with epigenetic regulation and therapeutic resistance. Its study remains critical for understanding neurodevelopmental disorders and cancer biology.