CRYGS抗体—艾普蒂

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse eye tissue lysate, Primary antibody: P09358(CRYGS Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

CRYGS (Crystallin Gamma S) is a member of the crystallin protein family, primarily expressed in the vertebrate eye lens. Crystallins, including α-, β-, and γ-subfamilies, are critical for maintaining lens transparency and refractive index. Among γ-crystallins, CRYGS is a key structural component that contributes to lens elasticity and optical clarity by preventing protein aggregation. Mutations in the CRYGS gene are associated with congenital cataracts, highlighting its role in lens homeostasis.

CRYGS antibodies are immunological tools designed to detect and study the expression, localization, and function of the CRYGS protein. These antibodies are widely used in research to investigate lens development, aging, and cataractogenesis. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize CRYGS distribution in lens tissues or cell models. Studies utilizing CRYGS antibodies have explored its interaction with other crystallins, stress-response pathways, and mechanisms underlying lens opacification. Additionally, they aid in characterizing animal models of cataracts or transgenic systems with CRYGS alterations. Commercially available CRYGS antibodies are typically validated for specificity via knockout controls or peptide blocking assays. Ongoing research focuses on CRYGS's potential role beyond the lens, including possible involvement in non-ocular tissues, though its primary significance remains in ocular biology and disease.