BATF抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09350(BATF Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09350(BATF Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The BATF (Basic Leucine Zipper Transcription Factor) antibody is a crucial tool for studying the BATF protein, a member of the AP-1 transcription factor family. BATF plays a pivotal role in immune regulation, particularly in lymphocyte differentiation and function. It forms heterodimers with Jun proteins to regulate gene expression, influencing T-cell differentiation (e.g., Th17 cells), B-cell antibody class switching, and dendritic cell development. Dysregulation of BATF is linked to autoimmune diseases, allergies, and cancer, making it a target for therapeutic research.

BATF antibodies are widely used in immunoblotting (Western blot), immunofluorescence, chromatin immunoprecipitation (ChIP), and flow cytometry to detect BATF expression and localization. These antibodies help elucidate BATF's interaction with partner proteins (e.g., IRF4. JunB) and its role in transcriptional networks. Researchers employ BATF antibodies in both human and murine models, given the protein's conserved function across species. Validated antibodies are essential for specificity, as BATF shares structural homology with other AP-1 family members (e.g., BATF2. BATF3). Commercial BATF antibodies are typically raised against epitopes in the N-terminal or leucine zipper domains, with validation via knockout cell lines or siRNA knockdown. Their applications span immunology, oncology, and infectious disease studies, particularly in contexts like tumor microenvironment modulation or chronic viral infections.