BAIAP2L1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P09347(BAIAP2L1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09347(BAIAP2L1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

BAIAP2L1 (BAI1-associated protein 2-like 1), also known as IRTKS (insulin receptor tyrosine kinase substrate), is a member of the insulin receptor substrate protein family. It plays a critical role in regulating membrane curvature and actin cytoskeleton dynamics, particularly in forming and stabilizing cellular protrusions like filopodia and invadopodia. BAIAP2L1 interacts with phospholipids and other signaling molecules, influencing processes such as cell migration, endocytosis, and synaptic plasticity. Its expression is observed in various tissues, with notable roles in neuronal development and cancer metastasis.

BAIAP2L1 antibodies are essential tools for studying its function and localization. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect BAIAP2L1 expression levels and distribution in cells or tissues. Research has linked BAIAP2L1 dysregulation to neurological disorders (e.g., autism spectrum disorders) and cancers, where its overexpression may enhance invasive potential. Antibodies targeting specific domains (e.g., the I-BAR domain) help elucidate structural-functional relationships. Commercial BAIAP2L1 antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat models, supporting translational research in cell biology and disease mechanisms.