BAALC抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09346(BAALC Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The BAALC (Brain and Acute Leukemia, Cytoplasmic) antibody is a tool used to detect the BAALC protein, encoded by the BAALC gene located on chromosome 8q22.3. Initially identified in 2001. the BAALC gene gained attention for its role in hematopoietic malignancies, particularly acute myeloid leukemia (AML) and T-cell acute lymphoblastic leukemia (T-ALL). BAALC is highly expressed in immature hematopoietic cells and certain neuronal tissues, suggesting involvement in cell differentiation and proliferation. In leukemia, elevated BAALC expression correlates with poor prognosis, resistance to therapy, and disrupted cellular pathways linked to apoptosis and cell cycle regulation.

The BAALC antibody is primarily utilized in research to study BAALC protein expression patterns via techniques like immunohistochemistry, Western blotting, or flow cytometry. It aids in characterizing BAALC's biological functions, its role in leukemogenesis, and its potential as a diagnostic or prognostic biomarker. Studies also explore BAALC's interaction with other oncogenic proteins, such as MN1 or WT1. to unravel its contribution to disease progression. Despite its clinical relevance, BAALC's precise molecular mechanisms remain under investigation, driving ongoing research to exploit its therapeutic or diagnostic potential in hematologic cancers.