UNC13B抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09319(UNC13B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of UNC13B Antibody**

UNC13B, also known as Munc13-2. is a member of the UNC13 family of proteins, which are critical regulators of synaptic vesicle priming and neurotransmitter release. Primarily expressed in the brain, UNC13B interacts with syntaxin and other components of the SNARE complex to facilitate synaptic transmission. Its role in maintaining synaptic plasticity underscores its importance in neural communication and cognitive functions.

Antibodies targeting UNC13B are essential tools in neuroscience research, enabling the study of its expression, localization, and function in both healthy and diseased states. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate UNC13B’s distribution in neuronal tissues. Research has linked UNC13B dysregulation to neurological disorders, including epilepsy, schizophrenia, and neurodegenerative diseases like Alzheimer’s. Additionally, studies suggest its involvement in cancer, where altered synaptic protein expression may influence tumor progression.

The development of specific and validated UNC13B antibodies has advanced understanding of synaptic mechanisms and disease pathways. However, challenges remain in ensuring antibody specificity due to homology among UNC13 family members. Ongoing efforts focus on refining these reagents to support precise mechanistic studies and potential therapeutic targeting.