UFM1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09317(UFM1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The UFM1 (Ubiquitin-fold modifier 1) antibody is a crucial tool for studying the UFMylation pathway, a post-translational modification system involved in maintaining cellular homeostasis. UFM1. a ubiquitin-like protein (UBL), covalently attaches to target proteins via a cascade involving E1 (UBA5), E2 (UFC1), and E3 (UFL1) ligases. This process, termed UFMylation, regulates critical biological processes, including endoplasmic reticulum (ER) stress response, ribosome-associated quality control, and DNA repair. Dysregulation of UFM1 signaling has been linked to developmental disorders, neurodegenerative diseases, and cancers.

UFM1 antibodies are widely used to detect UFM1-conjugated proteins or free UFM1 in techniques like immunoblotting, immunofluorescence, and immunoprecipitation. Specific antibodies distinguish between unconjugated UFM1 (pro-UFM1) and its activated/processed forms, aiding in pathway activation studies. Research highlights UFM1's role in erythroid development, neuronal health, and tumor suppression, with knockout models showing embryonic lethality or tissue-specific defects. Recent studies also implicate UFMylation in autophagy-lysosome function and immune regulation, expanding its therapeutic relevance. Commercial UFM1 antibodies are typically raised against full-length or epitope-tagged human UFM1. validated for cross-reactivity in model organisms like mice and zebrafish.