UBR2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09315(UBR2 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The UBR2 antibody is a tool used to detect and study the Ubiquitin-Protein Ligase E3 Component N-Recognin 2 (UBR2), a key player in the N-end rule pathway, a ubiquitin-dependent protein degradation system. UBR2. part of the UBR box-containing E3 ubiquitin ligase family, recognizes specific N-terminal residues (e.g., bulky hydrophobic or basic amino acids) in substrate proteins, targeting them for proteasomal degradation via polyubiquitination. This pathway regulates diverse processes, including apoptosis, DNA repair, and nutrient sensing. UBR2 is particularly notable for its role in spermatogenesis, where it mediates the degradation of histones during sperm maturation, and in muscle development through interactions with transcription factors.

Antibodies against UBR2 are essential for investigating its expression, localization, and function in cellular and animal models. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Research utilizing UBR2 antibodies has linked its dysregulation to pathologies such as male infertility, neurodegenerative disorders, and cancer. For instance, UBR2 deficiency in mice causes defective sperm development, while its overexpression in tumors may promote genomic instability. These studies highlight UBR2’s dual role as a quality control regulator and potential therapeutic target. The antibody’s specificity and validation (e.g., knockout controls) are critical for reliable data, given the structural similarities among UBR family members.