UBOX5抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue lysates, Primary antibody: P09314(UBOX5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09314(UBOX5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09314(UBOX5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The UBOX5 antibody is designed to target UBOX5 (U-box domain-containing protein 5), a member of the U-box protein family characterized by a conserved U-box domain that mediates E3 ubiquitin ligase activity. UBOX5 functions in the ubiquitin-proteasome system, facilitating the transfer of ubiquitin molecules to substrate proteins, marking them for degradation or modulating their interactions. This post-translational modification regulates diverse cellular processes, including protein quality control, DNA repair, and stress response pathways. UBOX5 is implicated in maintaining genomic stability, cell cycle progression, and apoptosis, with dysregulation linked to cancers, neurodegenerative diseases, and immune disorders.

The UBOX5 antibody is widely used in research to study its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. It aids in exploring UBOX5's role in diseases and its potential as a therapeutic target. Commercial UBOX5 antibodies are typically validated for specificity and sensitivity across human and model organism samples. Researchers rely on these tools to dissect UBOX5's involvement in E3 ligase complexes and its substrates, advancing understanding of ubiquitination dynamics in health and disease.