UBE2E3抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue lysate, Primary antibody: P09306(UBE2E3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09306(UBE2E3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09306(UBE2E3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The UBE2E3 antibody is a tool used to detect ubiquitin-conjugating enzyme E2E3 (UBE2E3), a member of the E2 ubiquitin-conjugating enzyme family. UBE2E3 plays a critical role in the ubiquitin-proteasome system (UPS), facilitating the transfer of ubiquitin to substrate proteins, typically marking them for proteasomal degradation. This enzyme is involved in diverse cellular processes, including cell cycle regulation, DNA repair, and protein quality control. Dysregulation of UBE2E3 has been linked to diseases such as cancer, neurodegenerative disorders, and diabetes. For instance, studies suggest UBE2E3 influences pancreatic β-cell function by modulating insulin secretion pathways.

UBE2E3 antibodies are typically produced using immunogens derived from recombinant UBE2E3 protein fragments, enabling specificity in recognizing human, mouse, or rat isoforms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study UBE2E3 expression, localization, and interactions. Validated antibodies often undergo rigorous testing for cross-reactivity and batch consistency. Research leveraging UBE2E3 antibodies has advanced understanding of its role in ubiquitination cascades, particularly in pathological contexts like tumorigenesis or metabolic disorders. Commercial availability of these reagents supports ongoing exploration of UBE2E3 as a potential therapeutic target or biomarker in disease.