ANKRD27抗体—艾普蒂

The ANKRD27 antibody targets the ANKRD27 protein, also known as VARP or sVAP, encoded by the ANKRD27 gene in humans. This protein contains multiple ankyrin repeat domains and a VPS9 domain, suggesting roles in intracellular trafficking and membrane dynamics. ANKRD27/VARP interacts with RAB32 and RAB38 GTPases, regulating lysosome-related organelles and melanosome biogenesis. It also associates with the Retromer complex, influencing endosome-to-Golgi retrograde transport. Studies link ANKRD27 to neurological conditions, including Parkinson’s disease, through its interaction with LRRK2. a kinase mutated in familial PD. Additionally, it may modulate immune responses by affecting MHC class I trafficking. The ANKRD27 antibody is widely used in research to study protein localization, expression levels in disease models, and molecular pathways involving vesicular transport. Commercial antibodies are validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent investigations explore its potential as a biomarker or therapeutic target in neurodegenerative disorders and cancer. Ongoing research aims to clarify its precise mechanistic contributions to membrane trafficking and disease pathogenesis.