WASF1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: U251, Hela, NIH/3T3, K562, 293T cell lysates, Primary antibody: P09271(WASF1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09271(WASF1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The WASF1 antibody is a crucial tool for studying the WASF1 protein, also known as Wiskott-Aldrich syndrome protein family member 1 or SCAR/WAVE1. WASF1 belongs to the WAVE/SCAR family of proteins, which regulate actin cytoskeleton dynamics by activating the ARP2/3 complex, a key driver of branched actin network formation. This protein plays a vital role in cell motility, adhesion, and membrane protrusion processes, particularly in migrating cells. Dysregulation of WASF1 has been implicated in cancer metastasis, neuronal development, and immune cell function, making it a focal point in cancer biology and developmental research.

The WASF1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect WASF1 expression and localization in cells or tissues. Researchers employ it to investigate mechanisms underlying tumor invasion, epithelial-mesenchymal transition (EMT), and metastatic pathways. Additionally, it aids in exploring WASF1's interactions with signaling molecules such as Rac GTPase and its regulatory complexes. Commercial WASF1 antibodies are typically validated for specificity and sensitivity, often targeting conserved regions like the N-terminus. Understanding WASF1's role through antibody-based assays contributes to potential therapeutic strategies targeting cytoskeletal remodeling in diseases like cancer.