XPA抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HUVEC cell lysate, Primary antibody: P09266(XPA Antibody) at dilution 1/2000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

**Background of XPA Antibodies**

XPA (Xeroderma Pigmentosum group A) antibodies are tools used to study the XPA protein, a critical component of the nucleotide excision repair (NER) pathway. This pathway repairs bulky DNA lesions, such as UV-induced cyclobutane pyrimidine dimers or chemical adducts, ensuring genomic stability. Mutations in the *XPA* gene cause Xeroderma Pigmentosum (XP), a rare autosomal recessive disorder characterized by extreme UV sensitivity, predisposition to skin cancers, and neurological dysfunction.

The XPA protein acts as a scaffold, coordinating interactions between DNA damage recognition complexes (e.g., XPC-RAD23B) and downstream repair machinery. It binds damaged DNA and recruits repair factors like TFIIH and endonucleases (XPF-ERCC1) to excise lesions. XPA antibodies are essential for detecting XPA expression levels, localization, and interactions in research models. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate NER efficiency, study XP pathogenesis, or explore XPA’s role in cancer and aging.

Additionally, XPA antibodies aid in diagnosing XP subtypes and evaluating therapeutic strategies targeting DNA repair deficiencies. Their specificity and reliability make them vital for advancing molecular insights into genome maintenance mechanisms and associated diseases.