ZYX抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P09255(ZYX Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09255(ZYX Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

Zyxin is a cytoskeletal protein primarily localized at focal adhesions and cell-cell junctions, where it plays a critical role in regulating cell adhesion, migration, and mechanotransduction. It interacts with components of the actin cytoskeleton, such as α-actinin and VASP, and shuttles between adhesion sites and the nucleus, potentially influencing gene expression in response to mechanical stimuli. Zyxin's function is vital in processes like tissue repair, embryonic development, and cancer metastasis, where cellular mechanics and signaling are pivotal.

The ZYX antibody is a research tool designed to detect and study zyxin expression and localization in various biological contexts. It is widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize zyxin's distribution in cells or tissues. Studies employing this antibody have elucidated zyxin's role in maintaining focal adhesion dynamics, mediating cellular responses to mechanical stress, and its involvement in pathological conditions, including fibrosis and tumor progression. For instance, reduced zyxin levels have been associated with impaired cell migration, while its overexpression is linked to enhanced metastatic potential in cancers.

As a target in mechanobiology research, zyxin and its associated antibody provide insights into how physical forces regulate cellular behavior, offering potential therapeutic avenues for diseases influenced by mechanical dysregulation.