ZPBP2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09253(ZPBP2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

Zona Pellucida Binding Protein 2 (ZPBP2) is a sperm-specific protein critical for male fertility, primarily involved in sperm-egg interaction during fertilization. Located on the sperm surface, ZPBP2 facilitates binding to the zona pellucida, a glycoprotein matrix surrounding the oocyte, enabling sperm penetration and fertilization. Structurally, it contains conserved ZP-binding domains and cysteine-rich regions, suggesting roles in protein-protein interactions and structural integrity.

ZPBP2 antibodies are tools used in reproductive biology to study sperm function, maturation, and infertility mechanisms. They aid in detecting ZPBP2 expression in sperm samples, assessing protein localization via immunofluorescence, or quantifying levels through techniques like Western blot. Research links ZPBP2 mutations or dysregulation to asthenozoospermia (reduced sperm motility) and teratozoospermia (abnormal sperm morphology), highlighting its diagnostic potential in male infertility.

Studies in knockout mice models show that ZPBP2 deficiency leads to defective sperm acrosome formation and infertility, reinforcing its functional significance. Commercially available ZPBP2 antibodies are often validated for specificity in human or model organisms, supporting both basic research and clinical applications. Ongoing work explores ZPBP2's interplay with other seminal proteins and its role in assisted reproductive technologies, underscoring its relevance in understanding and addressing fertility challenges.