ZSCAN12抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09251(ZSCAN12 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09251(ZSCAN12 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ZSCAN12 antibody is a tool used to detect and study the ZSCAN12 protein, a member of the zinc finger and SCAN domain-containing (ZSCAN) family. ZSCAN12. encoded by the *ZSCAN12* gene in humans, is a transcription factor characterized by C2H2-type zinc finger motifs, which mediate DNA binding, and a SCAN domain involved in protein-protein interactions. This protein is implicated in transcriptional regulation, potentially influencing cell differentiation, proliferation, and embryonic development. Its expression has been observed in various tissues, including embryonic stem cells and certain cancers, suggesting roles in maintaining pluripotency or driving oncogenesis.

Research using ZSCAN12 antibodies has focused on elucidating its biological functions. Studies indicate that ZSCAN12 may regulate target genes by binding to promoter regions or interacting with chromatin modifiers, impacting epigenetic states. In cancer contexts, aberrant ZSCAN12 expression has been linked to tumor progression, making it a candidate biomarker or therapeutic target. The antibody is commonly employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein localization, expression levels, and interactions in cellular or tissue samples.

Commercially available ZSCAN12 antibodies are typically raised in hosts such as rabbits or mice, with validation data confirming specificity against human, mouse, or rat homologs. Researchers utilize these reagents to explore ZSCAN12’s role in development, disease mechanisms, and regulatory networks, advancing insights into its contributions to health and pathology.