ZNF300抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09238(ZNF300 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09238(ZNF300 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ZNF300 antibody is a research tool designed to target the ZNF300 protein, a member of the zinc finger protein (ZFP) family. Zinc finger proteins are characterized by conserved cysteine and histidine residues that form structural motifs critical for DNA or RNA binding, enabling roles in transcriptional regulation, chromatin remodeling, and cellular differentiation. ZNF300. located on human chromosome 19. contains a KRAB (Krüppel-associated box) domain, a repression module that recruits chromatin-modifying complexes to regulate gene expression. Studies suggest ZNF300 may participate in immune responses, apoptosis, and cancer progression, though its precise biological functions remain under investigation.

Antibodies against ZNF300 are primarily used in molecular and cellular biology to detect endogenous ZNF300 protein expression via techniques like Western blotting, immunofluorescence, or immunohistochemistry. These antibodies are typically raised in hosts such as rabbits or mice, with validation steps including knockout/knockdown controls to confirm specificity. Commercially available ZNF300 antibodies aid in exploring its expression patterns in tissues or disease models, particularly in cancer research, where ZNF300 has been implicated as a potential oncogene in certain malignancies. For example, elevated ZNF300 levels correlate with tumor progression and poor prognosis in some studies, highlighting its potential as a therapeutic target or biomarker. However, further research is needed to fully elucidate its mechanisms and clinical relevance.