ZNF263抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 60 μg, Lane: Human liver tissue lysate, Primary antibody: P09233(ZNF263 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 7 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09233(ZNF263 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ZNF263 antibody is a crucial tool for studying the zinc finger protein 263 (ZNF263), a transcription factor belonging to the C2H2-type zinc finger family. ZNF263 binds to GC-rich DNA sequences, regulating gene expression by repressing or activating target genes involved in diverse cellular processes, including chromatin remodeling, RNA splicing, and cell differentiation. It interacts with epigenetic modifiers like histone deacetylases (HDACs) and methyltransferases, linking it to transcriptional silencing and chromatin organization. ZNF263 is also implicated in diseases, such as cancer and developmental disorders, where its dysregulation may alter gene networks.

The antibody specifically detects ZNF263 in applications like Western blotting, ChIP-seq, immunofluorescence (IF), and immunohistochemistry (IHC). Most commercial ZNF263 antibodies are raised against epitopes within its N-terminal or C-terminal regions, often validated for species reactivity (e.g., human, mouse). Researchers use it to explore ZNF263's DNA-binding dynamics, its role in 3D genome architecture, and its interplay with co-repressors or co-activators. Additionally, the antibody aids in identifying ZNF263 mutations or expression changes in pathological contexts. Quality controls, such as knockout cell validation, ensure specificity, minimizing cross-reactivity with homologous zinc finger proteins. Overall, the ZNF263 antibody is vital for dissecting its regulatory mechanisms and disease associations.