ZBTB18抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09231(ZBTB18 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09231(ZBTB18 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ZBTB18 antibody is a crucial tool for studying the ZBTB18 protein, a transcription factor belonging to the zinc finger and BTB domain-containing (ZBTB) family. Also known as ZNF238 or RP58. ZBTB18 plays a pivotal role in neurodevelopment, including neuronal differentiation, cortical layer formation, and synaptic plasticity. Structurally, it contains an N-terminal BTB domain for protein interactions and C-terminal C2H2 zinc finger motifs for DNA binding, enabling its function as a transcriptional repressor. ZBTB18 regulates gene expression by recruiting chromatin-modifying complexes, such as histone deacetylases (HDACs), to suppress target genes involved in cell cycle progression and differentiation.

Antibodies targeting ZBTB18 are widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to investigate its expression, localization, and DNA-binding activity. These antibodies are typically raised in rabbits or mice and validated for specificity across human, mouse, and rat models. Research highlights ZBTB18's involvement in neurological disorders (e.g., intellectual disability, autism spectrum disorders) and cancers (e.g., glioblastoma, neuroblastoma), where its dysregulation correlates with tumor progression or impaired neurogenesis. Studies also explore its role in epigenetic regulation and interactions with pathways like Notch and Wnt. As such, ZBTB18 antibodies are vital for unraveling its contributions to development, disease mechanisms, and potential therapeutic targets.