ZNF24抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P09230(ZNF24 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09230(ZNF24 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09230(ZNF24 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The zinc finger protein 24 (ZNF24), also known as ZNF191 or KOXX, is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. It functions as a transcription factor by binding to GC-rich DNA sequences through its C2H2-type zinc finger motifs, regulating the expression of target genes involved in cellular processes such as proliferation, differentiation, and apoptosis. ZNF24 plays critical roles in embryonic development, neurogenesis, and tumorigenesis. Studies suggest it acts as a tumor suppressor in certain cancers (e.g., hepatocellular carcinoma) by inhibiting oncogenic pathways, while paradoxically promoting progression in others (e.g., breast cancer) via context-dependent mechanisms.

ZNF24 antibodies are essential tools for investigating its expression, localization, and functional interactions. These antibodies, often raised in rabbits or mice, enable the detection of ZNF24 in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation. Research utilizing ZNF24 antibodies has elucidated its role in regulating genes such as VEGF (vascular endothelial growth factor) and its involvement in diseases like glioblastoma and intellectual disability disorders. Additionally, ZNF24 antibodies aid in studying post-translational modifications and protein-protein interactions, providing insights into its regulatory networks. Their specificity and validation are crucial for ensuring accurate interpretation of ZNF24's biological and pathological significance.