ZNF131抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human testis tissue and Rat brain tissue lysates, Jurkat and Hela cell lysates, Primary antibody: P09225(ZNF131 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09225(ZNF131 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ZNF131 antibody is a crucial tool for studying the zinc finger protein 131 (ZNF131), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein family. ZNF131 functions as a transcription regulator, primarily binding to DNA through its multiple C2H2-type zinc finger domains. It is implicated in diverse biological processes, including cell proliferation, differentiation, and apoptosis, with emerging roles in cancer progression and embryonic development. Researchers utilize ZNF131 antibodies to investigate its expression patterns, subcellular localization, and interactions with other regulatory proteins in both normal and pathological states.

These antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments corresponding to specific regions of ZNF131 (e.g., N-terminal or C-terminal domains). Validated applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). High-affinity ZNF131 antibodies enable detection of endogenous protein levels across various tissues and cell lines, aiding in functional studies such as gene knockout or overexpression experiments. Quality validation often involves knockout (KO) cell controls to confirm specificity. As dysregulation of ZNF131 has been observed in cancers and neurological disorders, its antibodies serve as essential reagents for unraveling molecular mechanisms and potential therapeutic targets.