HDHD2抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P09214(HDHD2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09214(HDHD2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09214(HDHD2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain-Containing Protein 2) antibody is a tool used to study the HDHD2 protein, a member of the haloacid dehalogenase (HAD) superfamily. This enzyme family is characterized by conserved catalytic domains involved in hydrolyzing phosphoric acid esters, though HDHD2's specific substrates and biological roles remain poorly understood. HDHD2 is hypothesized to participate in cellular metabolism, signal transduction, or nucleic acid regulation due to structural similarities to other HAD phosphatases. It is expressed ubiquitously, with higher levels in tissues like the liver, kidney, and brain, suggesting organ-specific functions.

Research using HDHD2 antibodies primarily focuses on elucidating its physiological and pathological roles. The antibody is employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect HDHD2 expression, localization, and interactions. Studies have explored its potential involvement in neurodevelopmental disorders, cancer progression, and metabolic diseases, though findings remain preliminary. For instance, altered HDHD2 expression has been observed in certain cancers, implying a possible link to tumorigenesis. Additionally, genetic variants near the HDHD2 locus are associated with autism spectrum disorders, spurring interest in its neurological functions.

Despite these advances, HDHD2's mechanistic pathways and regulatory networks require further investigation. The antibody serves as a critical reagent in bridging these knowledge gaps, aiding in the validation of HDHD2's molecular interactions and therapeutic potential.