SPIC抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09205(SPIC Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

SPIC (Spi-C) antibody is a tool used to detect the SPIC protein, a transcription factor belonging to the ETS family, which shares structural homology with PU.1 and Spi-B. SPIC is encoded by the *SPIC* gene and plays a critical role in regulating gene expression in specific immune cell lineages. It is notably expressed in red pulp macrophages (RPMs) in the spleen, where it governs their differentiation and functional specialization, including iron recycling and erythrocyte clearance. SPIC is also implicated in B-cell development and the regulation of inflammatory responses, particularly in macrophages involved in tissue homeostasis and immune tolerance.

SPIC antibodies are widely utilized in research to study protein expression patterns, cellular localization, and functional roles in both physiological and pathological contexts. They are employed in techniques like immunohistochemistry, Western blotting, and flow cytometry. Studies using these antibodies have linked SPIC dysregulation to diseases such as atherosclerosis, autoimmune disorders, and certain cancers, where abnormal macrophage activity or B-cell dysfunction occurs.

Clinically, SPIC is explored as a potential biomarker for macrophage-related pathologies or hematological malignancies. However, challenges remain in standardizing antibody specificity across experimental models. Ongoing research aims to elucidate SPIC's interaction networks and therapeutic potential in modulating immune responses.