LRRC45抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cell lysate, Primary antibody: P09190(LRRC45 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09190(LRRC45 Antibody) at dilution 1/130. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09190(LRRC45 Antibody) at dilution 1/130. (Original magnification: ×200)    

  
  

**Background of LRRC45 Antibody**

LRRC45 (Leucine-Rich Repeat-Containing Protein 45) is a member of the leucine-rich repeat (LRR) protein family, characterized by repetitive structural motifs involved in protein-protein interactions, signaling pathways, and cellular organization. While the precise biological function of LRRC45 remains under investigation, studies suggest its potential role in ciliogenesis, microtubule dynamics, and cellular trafficking, with implications in cilia-related disorders, cancer, and neurological conditions.

LRRC45 antibodies are immunological tools designed to detect and study the expression, localization, and interactions of the LRRC45 protein in various experimental models. These antibodies are commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate LRRC45's tissue-specific distribution, subcellular localization (e.g., association with centrosomes or ciliary structures), and dysregulation in disease contexts.

Commercial LRRC45 antibodies are typically generated using immunogenic peptide sequences derived from conserved regions of the human or murine LRRC45 protein. They are available as monoclonal or polyclonal formats, often validated in specific applications. However, due to limited characterization of LRRC45 and potential cross-reactivity with other LRR family proteins, rigorous validation (e.g., knockout controls) is essential for ensuring antibody specificity. Current research utilizing LRRC45 antibodies aims to clarify its functional mechanisms, interactome, and therapeutic relevance in diseases linked to ciliary dysfunction or cellular misregulation.