SFXN1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: PC-3, MCF-7 and K562 cell, Human cerebrum tissue, Hepg2 cell, Human fetal liver tissue , Primary antibody: P09188(SFXN1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

The SFXN1 antibody is a research tool designed to detect and study the expression and function of sideroflexin-1 (SFXN1), a mitochondrial membrane protein implicated in cellular metabolism and homeostasis. SFXN1 belongs to the sideroflexin family, which is evolutionarily conserved and involved in serine transport, mitochondrial iron metabolism, and one-carbon cycle regulation. Recent studies highlight SFXN1's role in mitochondrial respiration, heme biosynthesis, and iron-sulfur cluster assembly, linking it to hematopoiesis, neurodegenerative disorders, and cancer progression.

Antibodies targeting SFXN1 are typically produced in immunized hosts (e.g., rabbits or mice) using peptide or recombinant protein immunogens. They enable detection of SFXN1 via techniques like Western blotting, immunofluorescence, or immunohistochemistry, aiding in elucidating its tissue distribution, subcellular localization, and expression changes under pathological conditions. Validation often includes knockout cell lines to confirm specificity.

SFXN1 antibodies are critical for exploring its interactions with mitochondrial complexes, metabolic reprogramming in tumors, and potential as a biomarker or therapeutic target. Researchers use these tools to investigate SFXN1's involvement in diseases like anemia, mitochondrial disorders, and metabolic syndromes, reflecting its emerging significance in cellular energy and iron homeostasis pathways.