POLDIP3抗体—艾普蒂

POLDIP3 (DNA Polymerase Delta Interacting Protein 3), also known as PDIP46 or SKAR, is a multifunctional protein involved in DNA replication, repair, and mRNA processing. It interacts with DNA polymerase δ to facilitate DNA synthesis and repair, while also participating in mTOR-mediated translational regulation by linking mRNA splicing to protein synthesis. POLDIP3 antibodies are essential tools for studying its roles in cellular processes such as genome stability, cell cycle progression, and stress responses. These antibodies enable the detection and localization of POLDIP3 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to explore POLDIP3's interactions with partners like PCNA and its involvement in diseases, including cancer and neurodegenerative disorders. Validated antibodies are critical for ensuring specificity, often confirmed through knockout controls or epitope mapping. Understanding POLDIP3's dual functions in nuclear and cytoplasmic pathways highlights its importance in maintaining cellular homeostasis, making targeted antibodies vital for mechanistic studies and potential therapeutic applications.