RNF114抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09181(RNF114 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

RNF114 (Ring Finger Protein 114) is a member of the ubiquitin E3 ligase family, characterized by its N-terminal C4HC3-type zinc finger motif and C-terminal RING domain. It plays a regulatory role in protein ubiquitination, influencing processes like cell cycle progression, immune response, and DNA damage repair. Studies link RNF114 to psoriasis pathogenesis, where it modulates inflammatory signaling by interacting with proteins like RIPK2 and enhancing NF-κB activation. It also acts as a viral restriction factor, targeting viral components for degradation via ubiquitination.

RNF114 antibodies are essential tools for detecting and studying this protein's expression, localization, and interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Research using these antibodies has revealed RNF114's dual role in cancer: it may act as an oncogene in certain contexts (e.g., promoting lung adenocarcinoma proliferation) or a tumor suppressor (e.g., inhibiting melanoma metastasis). Dysregulation of RNF114 correlates with disease progression in psoriasis, viral infections, and various cancers, making it a potential therapeutic target. Antibody-based studies continue to clarify its complex regulatory networks and disease associations.