UBE2U抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09179(UBE2U Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

UBE2U (Ubiquitin-Conjugating Enzyme E2 U) is a member of the E2 ubiquitin-conjugating enzyme family, which plays a critical role in the ubiquitin-proteasome system (UPS). This system regulates protein degradation, a tightly controlled process essential for cellular homeostasis, DNA repair, and signal transduction. UBE2U transfers ubiquitin molecules to substrate proteins, typically in concert with E3 ubiquitin ligases, marking targets for proteasomal degradation or functional modification. While many E2 enzymes are well-characterized, UBE2U remains less studied, though emerging evidence suggests its involvement in specific biological pathways, including cell cycle regulation and transcriptional control.

Antibodies targeting UBE2U are vital tools for investigating its expression, localization, and interactions in cellular contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of UPS components, including E2 enzymes, is linked to diseases such as cancer and neurodegenerative disorders, making UBE2U a potential biomarker or therapeutic target. Recent studies highlight UBE2U’s possible role in modulating tumor suppressor pathways or viral infection responses, though mechanistic details remain unclear. Research using UBE2U antibodies could clarify its physiological and pathological contributions, aiding drug discovery or diagnostic development. However, challenges persist in distinguishing UBE2U from homologous E2 enzymes, emphasizing the need for highly specific antibodies. Overall, UBE2U antibodies serve as key reagents to unravel the enzyme’s functions and its implications in disease.