MOB4抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal brain tissue , Human cerebrum tissue, Mouse brain tissue, Primary antibody: P09176(MOB4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09176(MOB4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09176(MOB4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

MOB4 (MOB kinase activator 4) is a member of the MOB protein family, which plays critical roles in regulating cell cycle progression, signal transduction, and tissue homeostasis. Initially identified as a homolog of yeast Mob1. MOB4 is involved in the Hippo signaling pathway, a conserved pathway controlling organ size, cell proliferation, and apoptosis by modulating the activity of kinases like NDR (nuclear Dbf2-related) and LATS (large tumor suppressor). Unlike other MOB family members (e.g., MOB1), MOB4 lacks a conserved N-terminal domain and exhibits distinct functional interactions, suggesting divergent regulatory mechanisms.

MOB4 antibodies are essential tools for studying its expression, localization, and interactions in cellular processes. Research indicates MOB4 participates in mitotic regulation, potentially influencing centrosome dynamics and spindle assembly. Dysregulation of MOB4 has been implicated in cancer, with studies linking its overexpression or altered activity to tumorigenesis and genomic instability. Antibodies targeting MOB4 enable detection via techniques like Western blot, immunofluorescence, and immunohistochemistry, aiding investigations into its role in development and disease. However, its precise molecular mechanisms and pathway crosstalk remain under exploration, highlighting the need for reliable research tools to unravel its biological and pathological significance.