FAM3D抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HT-29 cell lysate, Primary antibody: P09175(FAM3D Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09175(FAM3D Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09175(FAM3D Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

The FAM3D antibody is a research tool designed to study FAM3D (family with sequence similarity 3. member D), a protein belonging to the FAM3 family of cytokine-like molecules. FAM3D is primarily expressed in the gastrointestinal tract, particularly in intestinal epithelial cells, and has gained attention for its dual roles in metabolic regulation and immune response modulation. Structurally resembling chemokines, FAM3D is implicated in activating G protein-coupled receptors (GPCRs) and influencing pathways related to energy homeostasis, inflammation, and gut barrier integrity. Research suggests it may interact with receptors like CXCR2. linking it to neutrophil recruitment and mucosal immunity. Its involvement in metabolic disorders (e.g., obesity, diabetes) and inflammatory bowel diseases (IBD) has made it a target for mechanistic studies.

The FAM3D antibody, typically developed in rabbit or mouse models, enables the detection and localization of FAM3D protein in tissues and cells via techniques like Western blotting, immunohistochemistry, and flow cytometry. It aids in exploring FAM3D’s secretion patterns, receptor interactions, and tissue-specific expression under physiological or pathological conditions. Validated for specificity and sensitivity, this antibody supports investigations into FAM3D’s role in gut-liver axis communication, immune cell trafficking, and its potential as a therapeutic biomarker. Ongoing studies leverage this tool to dissect FAM3D’s contributions to metabolic inflammation and its crosstalk with microbiota, advancing understanding of metabolic-immune interfaces.