TRAPPC4抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human bladder transitional cell carcinoma cancer next level 2-3 tissue lysate, Primary antibody: P09166(TRAPPC4 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09166(TRAPPC4 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09166(TRAPPC4 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

The TRAPPC4 antibody is a valuable tool for studying the role of TRAPPC4 (Transport Protein Particle Complex subunit 4), a core component of the TRAPP (TRAnsport Protein Particle) complex involved in intracellular membrane trafficking. TRAPP complexes are conserved multiprotein assemblies that regulate vesicle-mediated transport between the endoplasmic reticulum, Golgi apparatus, and endosomes. TRAPPC4. along with other TRAPP subunits, facilitates nucleotide exchange on Rab GTPases, particularly Rab1 and Rab11. which are critical for vesicle tethering and fusion.

Antibodies targeting TRAPPC4 enable researchers to investigate its expression, localization, and interactions in various cellular processes, including autophagy, cytokinesis, and organelle biogenesis. Dysregulation of TRAPPC4 has been implicated in neurodevelopmental disorders, cancer, and rare genetic conditions like congenital glycosylation defects. For example, mutations in TRAPPC4 are linked to autosomal recessive intellectual disability and microcephaly.

Commercial TRAPPC4 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences specific to human TRAPPC4. They are validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation. Proper controls, including knockout cell lines or siRNA-mediated knockdown, are essential to confirm antibody specificity. Researchers utilize these antibodies to explore TRAPPC4's molecular mechanisms, its role in disease pathogenesis, and its potential as a therapeutic target.