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  • GAR1抗体—艾普蒂
  • GAR1抗体—艾普蒂
  • GAR1抗体—艾普蒂

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GAR1抗体—艾普蒂

Rabbit Polyclonal GAR1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
GAR1抗体
英文名称：
Rabbit Polyclonal GAR1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4627 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
GAR1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesNOLA1
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human left kidney tissue and Human fetal liver tissue lysates, Primary antibody: P09163(GAR1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09163(GAR1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09163(GAR1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于GAR1抗体的3篇文献示例(内容基于真实研究概括，但文献名称和作者为虚拟示例，仅供参考)：

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1. **文献名称**: *GAR1 mediates telomerase RNA localization and stability in human cells*

**作者**: Smith A, et al.

**摘要**: 研究利用GAR1抗体通过免疫沉淀和RNA干扰，揭示了GAR1蛋白在端粒酶RNA(hTR)的核内定位和稳定性维持中的关键作用，缺失GAR1会导致端粒酶活性下降及细胞衰老。

2. **文献名称**: *Structural insights into the interaction between GAR1 and dyskerin in the H/ACA RNP complex*

**作者**: Chen L, et al.

**摘要**: 通过GAR1抗体的免疫共沉淀及冷冻电镜技术，解析了GAR1与dyskerin(DKC1)在H/ACA核糖核蛋白复合体中的相互作用界面，为遗传性疾病(如先天性角化不良症)的分子机制提供依据。

3. **文献名称**: *GAR1 expression correlates with cancer progression and predicts poor prognosis in hepatocellular carcinoma*

**作者**: Wang Y, et al.

**摘要**: 采用GAR1抗体的免疫组化分析发现，GAR1在肝癌组织中高表达，且与肿瘤分期、转移及患者生存率显著相关，提示其作为潜在癌症生物标志物的价值。

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如需具体文献，建议通过PubMed或Google Scholar检索关键词“GAR1 antibody”或“GAR1 telomerase”获取最新研究。

       

背景信息

The GAR1 antibody targets GAR1 (GAR1 ribonucleoprotein), a crucial component of the H/ACA small nucleolar ribonucleoprotein (snoRNP) complex involved in ribosomal RNA (rRNA) processing and telomerase stabilization. GAR1. encoded by the GAR1 gene, interacts with dyskerin, NHP2. and NOP10 to guide site-specific pseudouridylation of rRNA, essential for ribosome biogenesis and function. Dysregulation of H/ACA snoRNPs is linked to ribosomopathies and cancer, particularly due to their role in telomere maintenance via telomerase RNA maturation.

In cancer, GAR1 overexpression is observed in certain malignancies, correlating with enhanced telomerase activity and cell proliferation. GAR1 antibodies have thus been explored as tools to study snoRNP dynamics in oncogenesis. Additionally, GAR1 autoantibodies are implicated in autoimmune diseases, notably systemic sclerosis (scleroderma), where they serve as potential biomarkers. Their presence may reflect molecular mimicry or aberrant immune responses targeting snoRNP components.

Research on GAR1 antibodies focuses on their diagnostic utility, mechanistic roles in disease, and therapeutic targeting. Challenges include elucidating their precise pathogenic contributions and optimizing detection methods. Overall, GAR1 antibodies represent valuable probes for understanding snoRNP biology and developing biomarkers or therapies for cancer and autoimmune disorders.

       
GAR1抗体;GAR1;GAR1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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